2024 SETAC North America Poster: The bioaccumulation and metabolism of 6PPD-quinone in Rainbow Trout

2024 SETAC North America Poster: The bioaccumulation and metabolism of 6PPD-quinone in Rainbow Trout

6PPD-quinone (6PPD-Q), a transformation product of the antiozonant and antioxidant 6PPD (N-(1,3-Dimethylbutyl)-N′-phenyl-phenylenediamine), is believed to be carried from tire and road wear particles (TRWP) into watercourses. Some publications have identified 6PPD-Q as a contributor to Urban Runoff Mortality Syndrome (URMS) of a single specific fish species, Coho salmon.

The bioaccumulation potential of 6PPD-Q in rainbow trout (Oncorhynchus mykiss) was investigated by exposure to [14C]-6PPD-Q at a single test concentration according to the OECD 305 bioaccumulation guideline.  

Additionally, the metabolism of 6PPD-Q was investigated in the fish tissues sampled at the end of the exposure phase. This poster will present the results of the bioaccumulation study and the metabolism of 6PPD-Q observed in rainbow trout.

Rory Mumford will present this research at the SETAC North America 45th Annual Meeting in Fort Worth, Texas.

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