Ecotoxicology Studies
Our scientists are knowledgeable in testing challenging materials and analytically confirming exposure levels in low parts per trillion (ppt) range in a variety of sediment, soil, diets and aquatic matrices.
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SETAC Europe Poster: US EPA Chronic Mysid Testing Guideline
The U.S. Environmental Protection Agency (EPA) OPPTS 850.1350 Mysid Chronic Toxicity Test (draft, 1996) is conditionally required (40 CFR Part 158.630) for the registration of pesticide products in the U.S. Although this study is not required by regulatory agencies outside of North America, results have an impact on product registrations across the globe if the endpoint drives the risk assessment.
The primary challenges with successful completion of this study are due to a lack of detailed information within the EPA test guideline (TG) on the study design and conduct. Issues with test organism performance may result in studies that do not meet acceptability criteria, necessitating a study repeat.
CropLife America (CLA) has previously identified issues concerning the language in the existing TG, including: 1) Lack of clarity about study endpoints; 2) Limited guidance for handling the second generation (G2) populations; 3) Difficult to achieve data quality objectives for growth and reproduction; and 4) A need to update procedures to reflect methodological improvements following 20+ years of laboratory experience in performing this study. A joint CLA-CLE (CropLife Europe) project was undertaken to review issues with study design and subsequently develop recommendations for the modernization of the test guideline (TG).
The poster authors presented this research at the SETAC Europe 33rd Annual Meeting, 30 April – 4 May 2023, in Dublin, Ireland.